منابع مشابه
Self-renewal and differentiation
The adult human heart has limited regenerative capacity and, theref fore, functional restoration of the damaged heart presents a great challenge. Despite the progress achieved in the pharmacological and surgical treatment of degenerative myocardial diseases, they are still considered a major cause of morbidity and mortality in the western world. Repopulation of the damaged heart with cardiomyof...
متن کاملMolecular signatures of self-renewal, differentiation, and lineage choice in multipotential hemopoietic progenitor cells in vitro.
The molecular mechanisms governing self-renewal, differentiation, and lineage specification remain unknown. Transcriptional profiling is likely to provide insight into these processes but, as yet, has been confined to "static" molecular profiles of stem and progenitors cells. We now provide a comprehensive, statistically robust, and "dynamic" analysis of multipotent hemopoietic progenitor cells...
متن کاملDNA damage-induced Lok/CHK2 activation compromises germline stem cell self-renewal and lineage differentiation.
Stem cells in adult tissues are constantly exposed to genotoxic stress and also accumulate DNA damage with age. However, it remains largely unknown how DNA damage affects both stem cell self-renewal and differentiation. In this study, we show that DNA damage retards germline stem cell (GSC) self-renewal and progeny differentiation in a Lok kinase-dependent manner in the Drosophila ovary. Both h...
متن کاملPL-04 Regulation of self-renewal, proliferation and differentiation in an adult stem cell lineage
to connect cells together is ‘‘adherens junction (AJ)’’, which comprises cadherin receptors, associated proteins termed catenins, and cytoskeletons. The cadherin–catenin complex interacts with actin filaments via a-catenin. Recent analysis identified linkers between a-catenin and F-actin. The presence or absence of such linkers can alter the morphology of cell junctions, epithelial or mesenchym...
متن کاملThe level of DNA methylation impacts self-renewal capacity and lineage choices of hematopoietic stem cells
zur Erlangung des akademischen Grades d o c t o r r e r u m n a t u r a l i u m
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2018
ISSN: 1934-5909
DOI: 10.1016/j.stem.2017.12.016